Selective alkylation of nucleic acids by carcinogens may cause miscoding in DNA. A theoretical study.-论文-万方医学网

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Selective alkylation of nucleic acids by carcinogens may cause miscoding in DNA. A theoretical study.

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摘要：

The CNDO/II method was used to study the pairing abilities of various alkylated nucleic acids. On the basis of these results, a mechanism for mutation (carcinogenesis) is proposed. Our calculations suggest that O-(6) alkylated guanine and/or O-(4) alkylated thymine could cause miscoding during the replication of DNA.

作者： G,Klopman ; A,Ray

期刊：

《Cancer biochemistry biophysics》 1982年6卷1期31-5页

主题词：烷化剂(Alkylating Agents);烷化作用(Alkylation);致癌物(Carcinogens);DNA(DNA);DNA复制(DNA Replication);基因(Genes);遗传密码(Genetic Code);鸟嘌呤(Guanine);模型, 生物学(Models, Biological);构效关系(Structure-Activity Relationship);胸腺嘧啶(Thymine)

PMID： 7093936

发布时间： 2013-11-21

翻译满意度评价：: 准确一般字义偏差语意偏离译文作用小提交

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