Selective alkylation of nucleic acids by carcinogens may cause miscoding in DNA. A theoretical study.
摘要:
The CNDO/II method was used to study the pairing abilities of various alkylated nucleic acids. On the basis of these results, a mechanism for mutation (carcinogenesis) is proposed. Our calculations suggest that O-(6) alkylated guanine and/or O-(4) alkylated thymine could cause miscoding during the replication of DNA.
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