Neutral glycolipid composition in human cancer.
Neutral glycolipid composition of human gastric and colonic cancer was studied in comparison to healthy mucosa. The following compounds were identified: galactosylceramide, glucosylceramide, trihexosylceramide, globoside, small amounts of neotetraosylceramide and fucoglycolipids. The latter comprised both 3-0- and 4-0-substituted residues of N-acetylglucosamine. In cancer tissue the contents of lactosylcermide and of fucoglycolipids were increased. Fatty acid compositions of neutral glycolipids derived from both cancer and control samples were similar. The most abundant fatty acids were palmitic and nervonic acids.更多