Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
第一作者:
S R,Hubbard
第一单位:
Department of Pharmacology and Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York University Medical Center, New York, NY 10016, USA. hubbard@tallis.med.nyu.edu
作者:
主题词
腺苷酰亚氨二磷酸(Adenylyl Imidodiphosphate);氨基酸序列(Amino Acid Sequence);氨基酸取代(Amino Acid Substitution);动物(Animals);细胞系(Cell Line);结晶学, X线(Crystallography, X-Ray);酶激活(Enzyme Activation);人类(Humans);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);诱变, 定点(Mutagenesis, Site-Directed);肽类(Peptides);磷酰化(Phosphorylation);蛋白质构象(Protein Conformation);蛋白质结构, 二级(Protein Structure, Secondary);受体, 胰岛素(Receptor, Insulin);重组蛋白质类(Recombinant Proteins);转染(Transfection)
DOI
10.1093/emboj/16.18.5572
PMID
9312016
发布时间
2018-11-13
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The EMBO journal
5572-81页
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