Metformin targets multiple signaling pathways in cancer

摘要:

Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 dia-betes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin-like growth factor, c-Jun N-terminal kinase/mitogen-activated protein kinase (p38 MAPK), human epidermal growth factor receptor-2, and nuclear factor kappaB pathways. In addi-tion, cutting-edge targeting of cancer stem cells by metformin is summarized.

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作者单位: Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Educa-tion, Nanning 530021, Guangxi, P. R. China;Center for Translational Medicine, Guangxi Medical University, 14th Floor, Pharmacology and Biomedical Sciences Building, No. 22 Shuangyong Road, Nanning 530021, Guangxi, P. R. China [1] School for International Education, Guangxi Medical University, Nanning 530021, Guangxi, P. R. China [2] Department of Urology and Pathol-ogy, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA [3] Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncol-ogy in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, P. R. China [4] Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Educa-tion, Nanning 530021, Guangxi, P. R. China;Center for Translational Medicine, Guangxi Medical University, 14th Floor, Pharmacology and Biomedical Sciences Building, No. 22 Shuangyong Road, Nanning 530021, Guangxi, P. R. China;Department of Urology and Pathol-ogy, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA [5]
期刊: 《癌症(英文版)》2017年36卷7期 289-297页 ISTICCA
栏目名称: Review
DOI: 10.1186/s40880-017-0184-9
基金项目:
National Natural Science Foundation of China (NSFC) Key Project 81130046 NSFC81171993 NSFC81272415 Guangxi Key Projects 2013GXNSFEA053004 Guangxi Projects 1355004-5 2012GXNSFCB053004 Guangxi Ministry of Education 201202ZD022 201201ZD004 (to JZ). The authors thank Ms. Xin Huang and Ms. Xiaolin Zhou for editing
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