Autophagy and multidrug resistance in cancer

摘要:

Multidrug resistance (MDR) occurs frequently after long-term chemotherapy,resulting in refractory cancer and tumor recurrence.Therefore,combatting MDR is an important issue.Autophagy,a self-degradative system,universally arises during the treatment of sensitive and MDR cancer.Autophagy can be a double-edged sword for MDR tumors:it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive.Autophagy induced by anticancer drugs could also activate apoptosis signaling pathways in MDR cells,facilitating MDR reversal.Therefore,research on the regulation of autophagy to combat MDR is expanding and is becoming increasingly important.We summarize advanced studies of autophagy in MDR tumors,including the variable role of autophagy in MDR cancer cells.

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作者单位: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, P.R.China [1] Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, P.R.China;Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St.John's University, Queens, NY 11439, USA [2]
期刊: 《癌症(英文版)》2017年36卷8期 342-351页 ISTICCA
栏目名称: Review
DOI: 10.1186/s40880-017-0219-2
基金项目:
This study was supported by the Science and Technology Program of China the Natural Science Foundation of Guangdong Province the Program for New Century Excellent Talents in University the project was supported by Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
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