Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression

摘要:

Ferroptosis, a novel mode of non-apoptotic cell death,involves a metabolic dysfunction that results in the productionof iron-dependent reactive oxygen species (ROS),an iron carrier protein (transferrin), intracellular metabolicprocess, and related regulators (e.g., p53 protein).Previous studies have linked ferroptosis with oncogenicRas [1], and p53 tumor suppressor positively regulatesferroptosis by transcriptionally inhibiting the expressionof the cysteine/glutamate antiporter, which is encoded bythe SLC7A11 gene in human [1, 2]. Whether other factorssuch as epigenetic factors are involved in the processremains less known.

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作者单位: Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Educa-tion,Xiangya Hospital,Central South University,Changsha 410008,Hunan,P.R.China;Key Laboratory of Carcinogenesis,Ministry of Health,Cancer Research Institute,School of Basic Medicine,Central South University,Changsha 410078,Hunan,P.R.China [1] Institute of Medical Sciences,Xiangya Hospital,Central South University,Changsha 410008,Hunan,P.R.China [2] Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Educa-tion,Xiangya Hospital,Central South University,Changsha 410008,Hunan,P.R.China;Key Laboratory of Carcinogenesis,Ministry of Health,Cancer Research Institute,School of Basic Medicine,Central South University,Changsha 410078,Hunan,P.R.China;Department of Tho-racic Surgery,Second Xiangya Hospital,Central South University,Chang-sha 410011,Hunan,P.R.China [3]
期刊: 《癌症(英文版)》2017年36卷12期 669-671页 ISTICCA
栏目名称: Research Highlight
DOI: 10.1186/s40880-017-0248-x
基金项目:
the National Natural Science Foundation of China [81372427 and 81672787 81271763 and 81672991 (S. Liu)], and the National Basic Research Program of China
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