Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression

摘要:

Ferroptosis, a novel mode of non-apoptotic cell death,involves a metabolic dysfunction that results in the productionof iron-dependent reactive oxygen species (ROS),an iron carrier protein (transferrin), intracellular metabolicprocess, and related regulators (e.g., p53 protein).Previous studies have linked ferroptosis with oncogenicRas [1], and p53 tumor suppressor positively regulatesferroptosis by transcriptionally inhibiting the expressionof the cysteine/glutamate antiporter, which is encoded bythe SLC7A11 gene in human [1, 2]. Whether other factorssuch as epigenetic factors are involved in the processremains less known.

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