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乐山市沙湾区已婚育龄妇女人乳头状瘤病毒感染现状

The analysis of the present situation of human papillomavirus infection in married women of childbearing age in Chengdu City

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目的 探讨乐山市沙湾区已婚育龄妇女人乳头状瘤病毒感染的危险因素及干预效果.方法 选取乐山市沙湾区已婚育龄妇女512例作为研究对象.采用问卷调查方式对人乳头状瘤病毒(HPV)感染因素进行分析.将HPV感染阳性患者根据患者个人意愿分为对照组、中药组及干扰素组.对照组11例,无干预措施.中药组22例,采用口服中药方剂及阴道清洁干预.干扰素组患者10例,给予α干扰素与转移因子联合治疗干预.结果 已婚育龄妇女512例,共43例患者HPV感染阳性,感染率8.4%.不同文化程度已婚育龄妇女HPV感染率,差异有统计学意义(P<0.05).不同受孕次数、性生活频率及尿路感染已婚育龄妇女HPV感染率,差异有统计学意义(P<0.05).不同基因型已婚育龄妇女HPV感染率,差异有统计学意义(P<0.05).经不同干预治疗后,三组患者疗效差异有统计学意义(P<0.05).随访1个月时,干扰素组患者治疗效果最好.继续随访发现,中药组患者HPV疗效更加明显.结论 不同文化程度、受孕次数、性生活频率及尿路感染是HPV感染危险因素,HPV感染基因类型中以16和18混合感染发生率最高,HPV感染的中药治疗临床疗效良好.

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abstracts:

Objective To investigate the risk factors of the human papilloma virus infection in married women of childbearing age in the city of Chengdu and the effect of intervention.Methods 512 cases of married women of childbearing age were selected as the research object in Chengdu city.The infection factor of human papilloma virus (HPV) was analyzed by way of questionnaire.According to the patient's personal wishes,HPV positive patients were divided into the control group,the traditional Chinese medicine group and interferon group.Control group,11 cases,had no intervention measures.The traditional Chinese medicine group,22 cases,had been treated with oral administration of Chinese medicines and vaginal cleaning intervention.Interferon group,10 cases,were given the combined treatment,alpha interferon and transfer factor intervention.Results 43 patients in 512 cases were positive for HPV infection,the infection rate was 8.4%.There was significant difference (P < 0.05) between different groups for different cultural level,the number of different conception,the frequency of sexual life and urinary tract infection of married women of childbearing age.Follow up of 1 months treatment,the best therapeutic effect was interferon group patients.Continued follow-up showed that patients with HPV traditional Chinese medicine group was more obvious.Conclusions Different education level,pregnant times,the frequency of sexual life and urinary tract infection were the risk factors for HPV infection.The infection of HPV gene type with 16 and 18 mixed infection was the highest type.Chinese medicine for the treatment of HPV infection was good clinical efficacy.

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