耐甲氧西林金黄色葡萄球菌可移动基因元件——SCCmec的研究进展
Progress of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus
耐甲氧西林金黄色葡萄球菌(MRSA)能够导致从浅表皮肤感染到严重坏死性肺炎等各种感染.致病性强、多重耐药程度高是其特征.存在于MRSA上的mecA基因介导对甲氧西林和所有其他的β-内酰胺类抗生素的耐药,mecA位于一个可移动的基因元件--SCCmec上面.目前已经检测出8种主要的SCCmec类型:Ⅰ~Ⅷ型.SCCmec分型作为研究MRSA分子流行病学特征的一个重要方法在不断的改进.
更多Staphylococcus aureus can cause a broad variety of infections, ranging from minor infections of the skin to serious necrotic pneumonia. Pathogenicity and high degree of multi-drug resistance are the characteristics of the methicillin-resistant Staphylococcus aureus ( MRSA ). The cause of resistance to methicillin and all other β-lactam antibiotics is the mecA gene, which is situated on a mobile genetic element, the staphylococcal cassette chromosome mec (SCCmec). Eight major variants of SCCmec, type Ⅰ to Ⅷ, are distinguished. This paper describes the structure and typing of SCCmec, its discovery, detection methods and distributiong are reviewed.
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