足糖萼蛋白在蛋白尿相关肾病足细胞损伤中的作用
Podocalyxin in podocyte injury of proteinuria associated nephropathy
足糖萼蛋白( podocalyxin,PCX)是CD34家族相关性跨膜糖蛋白,正常表达于肾脏足细胞、造血干细胞、血管内皮细胞及神经元中.作为足细胞顶面标志蛋白之一,其对维系正常足细胞形态和功能、阻止蛋白尿的产生有重要作用.足细胞损伤导致蛋白尿的发生机制是目前研究热点,PCX在其发病过程中起重要作用.该文就近年来PCX在蛋白尿相关肾病足细胞损伤中的研究进行综述.
更多Podocalyxin,a sialomucin most closely related to CD34,is expressed by kidney podocytes,hematopoietic progenitors,vascular endóthelia and a subset of neurons.As one of the important apical marker protein,podocalyxin plays an important role in the integrity of the structure and function of nomal podocyte,and is closely related to the prevention of proteinuria.The mechanism of podocyte injury associated with proteinuria remains unkown.The investigation of podocalyxin,a major podocyte protein,is significant in the pathogenesis and process of the primarily glomerulopathies.This paper summarizes the progresses of podocalyxin in podocyte injury of proteinuria associated nephropathy.
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