摘要维生素A缺乏是哮喘发病的危险因素之一.维生素A具有拮抗气道氧化性损伤、促进气道损伤的修复、抑制气道高反应、诱导免疫耐受、调节气道炎症等功能.维生素A用于哮喘防治成为研究热点,但其效益性仍存在争议.维生素A的受体广泛表达、信号通路复杂,维生素A与哮喘发病相关机制有待更深入的研究.目前,维生素A用于哮喘防治的临床研究已有报道,但结果尚不一致.哮喘是一种由环境和遗传因素共同作用的多基因遗传病,今后维生素A用于哮喘防治的基础和临床研究可结合遗传和环境的群体差异.该文就维生素A与哮喘关系的研究进展进行综述.

abstractsVitamin A deficiency is a risk factor for asthma.Vitamin A plays important roles in maintaining airway epithelium phenotype,suppressing airway hyperresponsiveness,inducing immune tolerance and regulating airway inflammation,etc.The value of Vitamin A in asthma prevention and treatment has received wild attention but is still controverial.Vitamin A receptors are wildly expressed and the mechanisms are complex,more studies are needed to further clarify the relationship between Vitamin A and asthma.Besides,asthma is a polygenetic disease caused by environmental and genetic factors,and the current clinical studies of Vitamin A for prevention and treatment of asthma are not consistent.New epidemiologic studies about Vitamin A and asthma should take environmental and genetic factors into consideration.This article gives an overview about the research progress of the relationship between Vitamin A and asthma.