P糖蛋白在白血病多药耐药中的调控机制
The regulatory mechanisms of P-glycoprotein in leukemia of multi-drug resistance
多药耐药(multidrug resistance,MDR)是导致白血病化疗失败的主要原因,白血病MDR的产生与细胞膜表面P糖蛋白(P-glycoprotein,P-gp)的药物转运作用直接相关,多种信号传导通路如MAPKs、NF-κB、Hedgehog、Wnt/β-catenin、PI3K/Akt参与调节P-gp的表达,而调控因子Stats、microRNA、TRAIL、HDACs也与P-gp的表达密切相关.该文就白血病MDR细胞中P-gp的表达调控机制的研究进展作一综述.
更多Multidrug resistance (MDR)has been a main reason for the failure of leukemia chemotherapy.The generation of MDR in leukemia is directly related to the transportation of drug efflux of P-glycoprotein (P-gp)on cell membrane surface.Many signaling pathways such as MAPK、NF-κB、Hedgehog、Wnt/β-catenin、 and PI3K/Akt involves in regulating of P-gp expression.Meanwhile, regulation factors including Stats、 microR-NA、TRAIL and HDACs are closely related to the P-gp expression.This review briefly discusses the progress of the regulatory mechanisms of P-gp in MDR of leukemia.
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