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Sox9是Sox家族E组中成员,Sox9在性别决定与分化、肿瘤的发生发展以及器官发育中发挥作用.胰腺发育过程中Sox9及其与Notch、Wnt、Fgf信号通路共同作用参与胰腺早期内分泌祖细胞的增殖与分化,是胰腺内分泌发育过程调控网络中的多潜能因子.内分泌β细胞是唯一分泌胰岛素的细胞.胰岛素分泌的绝对或相对不足会使血糖升高进而导致糖尿病的发生.研究胰腺内分泌发育是探究糖尿病发病机制的新思路.该文就Sox9基因及其转录调控机制对胰腺内分泌发育作用作一综述.

Sox9 is a member of the Sox family of E groups,and it plays a role in gender determination and differentiation,tumor development and organ development.In the process of pancreatic development,Sox9 and its crosstalk with the Notch,Wingless and INT-1 (Wnt) and fibroblast growth factor (Fgf) pathways are involved in the proliferation and differentiation of early pancreatic endocrine progenitor cells.It is a versatile factor of Sox9 in the regulation network of pancreatic endocrine development.Endocrine beta cells are the only cells that secrete insulin.The absolute or relative inadequate of insulin will lead to increase blood glucose levels and then lead to the occurrence of diabetes.The study of pancreatic endocrine development provides a new idea to explore the pathogenesis of diabetes.In this paper,the effects of Sox9 and its transcriptional regulation mechanisms on pancreatic endocrine development are summarized.