摘要目的 探讨维生素D对支气管哮喘(简称哮喘)患者Th1/Th2平衡的调节及IL-17的影响.方法 将80例稳定期哮喘患者随机分为对照组和治疗组各40例.对照组予以沙美特罗氟替卡松50/250 μg,每日1次,吸入治疗;治疗组在对照组基础上加用阿法骨化醇0.5 μg,每日1次,口服.2组治疗前均行γ干扰素(IFN-γ)、IL-4及IL-17检测,计算IFN-γ/IL-4比值,8周后复查上述指标.结果 治疗前两组IFN-γ和IL-4水平、IFN-γ/IL-4比值及IL-17基本一致(P＞0.05);治疗后IFN-γ/IL-4比值,治疗组明显高于对照组(P＜0.05),治疗组IL-17下降高于对照组(P＜0.05).结论 维生素D对哮喘患者的Th1/Th2平衡有一定的调节作用,可降低哮喘患者IL-17的过度表达.

abstractsObjective To investigate the regulation of vitamin D on Tb1/Th2 balance in patients with bronchial asthma (asthma) and the influence on interleukin-17 (IL-17).Methods Eighty patients with stable asthma were randomly divided into control group and treatment group with 40 cases in each.The control group was given Shah Mette Lo fluticasone inhalation in the treatment of 50/250 μg QD.The treatment group was added with alfacalcidot 0.5 μg QD oral on the basis of the control group.The two groups were examined by IFN-γ,IL-4 and IL-17 detection before treatment,calculation of IFN-γ/IL-4rati,checked the inidex after 8 weeks.Results Before treatment,the levels of IFN-γ and IL-4,IFN-γ/IL-4 ratio and IL-17 in the two groups were nearly the same (P ＞0.05).After treatment,IFN-γ/IL-4 ratio in the treatment group was significantly higher than that of control group (P ＜0.05),the decrease of IL-17 in the treatment group was higher than that in the control group (P ＜0.05).Conclusions In asthma patients,vitamin D have a regulatory role of Th1/Th2 balance,vitamin D can reduce the IL-17 overexpression in patients with asthma.