摘要目的：降钙素原(procalcitonin,PCT)用于细菌感染性肺部疾病中革兰阴性菌及革兰阳性菌的鉴定分析的初步探讨。方法对解放军总医院呼吸科2011年1月至2012年5月收住的186例中重症肺炎患者(包括社区获得性肺炎和医院获得性肺炎)进行回顾性分析,分为革兰阴性杆菌组(n =95)和革兰阳性球菌组(n =91),了解血清 PCT 等指标变化情况,采用受试者工作特征曲线比较 PCT 对于2种菌鉴别情况。结果研究病例中,革兰阳性球菌组 PCT 水平较革兰阴性杆菌组高(t =11.09,P <0.05)。PCT 在3.78μg/L 时,预测革兰阳性球菌感染的敏感性为80%,特异性为71%。结论在细菌感染性肺部疾病中,PCT 水平在革兰阳性菌感染时较革兰阴性菌高,通过 PCT 的数值水平可对细菌类别作出初步判定。

abstractsObjective To discuss the role of procalcitonin (PCT)in the identification of gram negative bacteria and gram positive bacteria in bacteria infection pulmonary disease.Methods 186 patients with pulmonary infection (including community acquired pneumonia and hospital acquired pneumonia) from January 201 1 to May 2012 in the people′s liberation army general hospital were retrospectively analyzed.They were divided into gram negative bacteria group (n =95)and gram positive bacteria group (n =91).The level of serum procalcitonin was detected,the bacteria identification condition of PCT was analyzes by the receiver operating characteristic curve.Results The level of PCT in gram positive bacteria group was markedly higher than that in gram negative bacteria group (t =1 1.09,P <0.05).When the level of PCT was 3.8 μg/L,the diagnostic sensitivity and specificity of gram positive bacterial infection were 80% and 71%,respectively.Conclusions In the bacterial infection lung diseases,PCT in gram positive bacteria infection is significantly increased compared with gram negative bacteria infection.The preliminary judgment on the bacterial category can be made through the level of PCT.