G试验联合GM试验对HIV合并侵袭性真菌感染的诊断价值
Diagnostic value of G test combined with GM test in HIV patients with invasive fungal infection
目的 探讨(1,3)-β-D-葡聚糖检测(G试验)联合半乳甘露聚糖检测(GM试验)对HIV感染者合并侵袭性真菌感染(IFI)的早期诊断价值.方法 回顾性分析广州市第八人民医院2016年1—6月住院的HIV/AIDS患者共268例,根据相关IFI诊断标准分为真菌感染组58例和非感染组210例,进行G试验和GM试验,分析联合检测结果.结果 G试验的灵敏度、特异性、阳性预测值、阴性预测值分别为70.69%、73.81%、42.71%、90.12%,GM试验分别为60.34%、87.14%、56.45%、88.83%;两者联合检测的诊断灵敏度为89.66%,特异性为99.05%.结论 G试验联合GM试验检测可提高IFI的诊断效能,降低漏诊率和误诊率,为HIV/AIDS合并IFI的早期诊治提供依据.
更多Objective To explore the early diagnostic value of(1,3)-β-D-glucan test(G test) and galactomannan test (GM test) in HIV patients with invasive fungal infection (IFI). Methods There were 268 HIV/AIDS cases enrolled in Guangzhou Eighth People's Hospital from January to June 2016. According to the relative criteria, the patients were divided into IFI group (58 cases) and non-IFI group (210 cases). The combined results of G test and GM test were retrospectively analyzed. Results The sensitivity, specificity, positive predict value and negative predict value of G test were 70.69%, 73.81%, 42.71% and 90.12%, respectively. At the same time, those of GM test were 60.34%, 87.14%, 56.45% and 88.83%,respectively. The sensitivity and specificity reached 89.66% and 99.05% in combined test. Conclusions G test combined with GM test can raise diagnostic efficiency for IFI as well as decreasing missed diagnosis rate and misdiagnosis rate, so as to provide early diagnostic evidence for IFI in HIV/AIDS patients.
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