甲真菌病患者外周血淋巴细胞免疫表型的分析
Analysis of lymphocyte immunophentypes in peripheral blood of onychomycosis patients with flow cytometry
目的 探讨甲真菌病患者外周血淋巴细胞免疫表型的情况.方法 应用流式细胞仪对24例甲真菌病患者及20例健康人的外周血淋巴细胞亚群和自然杀伤细胞进行测定与分析.结果 甲真菌患者外周血CD8+淋巴细胞明显高于健康对照组(P<0.05),而CD3+细胞,CD4+细胞,CD4+/CD8+、CD19+细胞、CD16+CD 56+细胞与对照组变化不明显.结论 甲真菌患者存在着一定程度的细胞免疫异常,以CD8+细胞介导的免疫反应占主要地位.
更多Objective To evaluate the immunological competence in peripheral blood of the patients with onychomycosis. Methods The lymphocyte subpopalations and natural killer cells in the peripheral blood of 24 patients and a control group of 20 individuals were analysed by flow cytometry. Results The percentage of suppressor CD8+ lymphocytes in the patients were significantly higher than that in the normal controls (P < 0.05 ). No statistically significant difference was obtained in the percentages of CD3+ lymphocytes,CD4+ lymphocytes, CD19+ lymphocytes, CD16+, CD56+ lymphocytes. Conclusion CD8+ lymphocytes plays an importand role in mediating the cell mediated immunity in onychomycosis.
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