检索历史 清除

哺乳动物的Toll样受体(TLR)家族具有模式识别受体的功能,其可以识别微生物的保守分子成分,启动机体的固有免疫系统,从而帮助机体清除病原体.利用TLR敲除的动物或细胞模型进行的研究使人们认识到TLR在机体抗病毒免疫反应中发挥着重要作用.病毒与宿主细胞的TLR结合后,通过NF-κB或IRF-3的信号路径激活细胞因子的表达,从而激发免疫应答.研究TLR如何与病原体结合及如何激活下游基因对深入认识病原体所致相关疾病的发病机制、免疫应答及病理生理具有重要的意义,并为病毒性疾病的临床治疗或免疫预防提供新的思路.

Toll-like receptors (TLR) play critical roles in initiating host innate immune system and eradica-ting the invading pathogens by recognizing conserved structures of microorganisms. TLR-defieient animalmodels and cell culture have provided us with immense knowledge on the function of TLRs in anti-viral innateimmune responses. Viruses activate TLRs and induce immune response through NF-κB or IRF-3. signaling pathway. Research on the relationship between TLR and virus and the mechanism of activating signaling cas-cade genes will help us to further understand the immune response and the pathogenesis of infectious disease,and provide new insights to the therapy and prevention on viral disease.