特异性细胞毒性T细胞在乙型肝炎病毒感染中的作用机制及其影响因素
The role of specific cytotoxic T cells in HBV infection and related influencing factors
乙型肝炎病毒(HBV)是一种嗜肝非细胞毒性病毒,感染机体后,诱导体内产生一系列免疫应答.此免疫应答既清除HBV病毒,同时引起肝细胞的炎症反应和损伤.研究表明,在机体免疫反应中,HBV特异性细胞毒性T淋巴细胞(CTL)对病毒的清除发挥重要作用,其与肝细胞直接接触或分泌细胞因子IFN-γ来清除病毒.近年来,国内外对特异性CTL在HBV感染过程中的作用机制进行了深入研究并取得了较大进展,为临床治疗提供了新策略.
更多Hepatitis B virus (HBV) is a kind of non-cytotoxic hepadnavirus.A series of immune responses are activated by HBV infection.The immune responses can act a role in HBV clearance.On the other hand, they can also induce the inflammatory response and damage of liver cells.Previous studies have demonstrated that HBV-specific cytotoxic T lymphocytes (CTLs) play an important role in virus clearance through their direct contact with hepatocytes or secretion of cytokine IFN-γ.Recently,the mechanisms of specific CTLs in the process of HBV infection had been carried out widely and thoroughly.These research findings provide a new strategy for clinical treatment of HBV infection.
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