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目的 探讨高压氧治疗高血压性脑出血对患者血清神经元特异性烯醇化酶(NSE)、转化生长因子β1(transforming growth factor,TGF-β1)、血管内皮功能及免疫功能的影响.方法 85例高血压性脑出血患者依据随机数据表法分为对照组(42例)和观察组(43例),对照组患者给予术后常规对症治疗,观察组患者在对照组的基础上给予高压氧治疗.比较治疗前后两组血清NSE、TGF-β1、血管内皮功能及免疫功能水平.结果 治疗前,两组的血清NSE、TGF-β1、一氧化氮(NO)、内皮素(ET)-1、CD3+、CD4+、CD8+、CD4+/CD8+水平比较,差异无统计学意义(P＞0.05).治疗后,两组TGF-β1、NO、CD4+、CD4 +/CD8+水平较组内治疗前均显著升高(P＜0.05),且观察组显著高于治疗后对照组,差异有统计学意义(P＜0.05);两组NSE、ET-1、CD8+水平均显著低于治疗前(P＜0.05),且观察组显著低于对照组,差异有统计学意义(P＜0.05);对照组治疗前后CD3+水平比较,差异无统计学意义(P＞0.05),观察组治疗后水平显著高于治疗前,且显著高于对照组,差异有统计学意义(P＜0.05).结论 高压氧治疗高血压性脑出血,可有效降低血清NSE水平,升高TGF-β1水平,改善患者血管内皮功能及免疫功能,具有重要临床价值.

Objective To investigate the effects of hyperbaric oxygen on serum neuronspecific enolase (NSE),transforming growth factor-β1 (TGF-β1),vascular endothelial function,and immune function in hypertensive intracerebral hemorrhage.Methods According to random data table method,85 cases of hypertensive intracerebral hemorrhage were randomly divided into the control group (n =42) and observation group (n =43),patients in the control group were given routine symptomatic treatment after operation,on the basis of the treatment of the control group,the observation group received hyperbaric oxygen.The levels of serum NSE,TGF-β1,vascular endothelial function and immune function were compared between the two groups before and after treatment.Results The levels of serum NSE,TGF-β1,nitric oxide (NO),endothelin (ET)-1,CD3 +,CD4 +,CD8 + andCD4 +/CD8 + in the two groups before treatmentwere not statistically significant (P ＞ 0.05).After treatment,The levels of TGF-β1,NO,CD4+ and CD4+/CD8 + in the two groups were significantly higher than those in the same group before treatment (P ＜ 0.05),and the observation group levels were significantly higher than those in the control group after treatment,the difference was statistically significant (P ＜ 0.05);The levels of NSE,ET-1 and CD8 + in the two groups after treatment were significantly lower than those in the same group before treatment (P ＜ 0.05),and the observation group was significantly lower than that of the control group,the difference was statistically significant (P ＜ 0.05);There were no statistically difference between before and after treatment in the control group CD3 + level(P ＞ 0.05),after treatment,the level of CD3 + of the observation group was significantly higher than before treatment,significantly higher than that of the control group,the difference was statistically significant (P ＜ 0.05).Conclusion Hyperbaric oxygen has important clinical value in the treatment of hypertensive intracerebral hemorrhage,it can effectively reduce the level of serum NSE,increase the level of TGF-β1,improve the vascular endothelial function and immune function.