首页 > 临床与病理杂志 > 膝关节骨性关节炎患者血清和滑膜液CC趋化因子配体18浓度及与疾病严重程度的关系

膝关节骨性关节炎患者血清和滑膜液CC趋化因子配体18浓度及与疾病严重程度的关系

Relationship between the concentration of CC-chemokine ligand 18 in serum and synovial fluid and the severity of knee joint in patients with osteoarthritis

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摘要目的:探究膝关节骨关节炎患者血清和滑膜液中CC趋化因子配体18(CC-chemokine ligand 18,CCL18)浓度及与疾病严重程度的关系.方法:纳入100例膝关节炎患者和70例健康对照者.采用Kellgren-Lawrence(KL)分级评估膝关节炎的严重程度;采用ELISA方法检测研究对象血清和滑膜液中CCL18浓度;用Spearman相关分析分析血清与滑膜液CCL18浓度间的相关性,血清、滑膜液CCL18浓度与KL分级间的相关性.结果:膝关节炎患者血清CCL18浓度显著高于健康对照者[(54.13±8.9)ng/mL vs(38.97±6.9)ng/mL,P<0.001],KL-4级患者血清CCL18浓度显著高于KL-3级患者[(72.26±12.90)ng/mL vs(49.56±10.3)ng/mL,P<0.05],KL-3级患者血清CCL18浓度显著高于KL-2级患者[(49.56±10.3)ng/mL vs(45.85±8.9)ng/mL,P<0.05].KL-4级患者滑膜液CCL18浓度显著高于KL-3级患者[(45.43±11.09)ng/mL vs(28.49±7.98)ng/mL,P<0.05];KL-3级患者滑膜液CCL18浓度显著高于KL-2级患者[(28.49±7.98)ng/mL vs(27.00±5.43)ng/mL,P<0.05].血清CCL18与滑膜液CCL18浓度显著正相关(r=0.425,P<0.001),血清和滑膜液CCL18与KL分级显著正相关(r=0.560,P<0.001;r=0.525,P<0.001).结论:血清和滑膜液中CCL18浓度与膝关节炎严重程度相关.