摘要精子发生是生殖细胞经历的一个复杂而独特的细胞增殖与分化过程,其中一些基因及特殊的蛋白因子、RNA、酶等都发挥着至关重要的作用.减数分裂是配子发生过程中一个重要的环节.参与精子发生减数分裂的相关因子非常多,它们的改变或缺失能够造成精子发生阻断,无法形成正常成熟精子,如Scp3、M1 ap、TEX11、Spata 22、Smc6、Ku70、TSF22等基因的缺失突变、相关因子及酶的缺失,都将影响第一次减数分裂,进而影响精子发生.本文将对这些影响第一次减数分裂的相关因子作一综述.

abstractsSpermatogenesis is a highly complex and unique process of cell proliferation and differentiation in reproductive cells.Spermatogenesis is controlled by many factors;among them some genes and specific protein factors,RNAs,enzymes play essential roles.Meiosis is an important link in the process of spermatogenesis.There are lots of associated factors in meiosis and spermatogenesis whose change or deletion can affect the spermatogenesis and disable the formation of a normal mature sperm.The deletion mutation of genes such as Scp3 、M1 ap、TEX11、Spata22、Smc6 、Ku70、TSF22,and absence of correlation factors and enzymes,can also affect the first meiotic division and spermatogenesis.In this paper,we review these factors that influence the first meiosis division.