转录因子SOX9与肿瘤发生的关联
Transcription factor SOX9: its associations with cancer
SOX9是与性别决定密切相关的转录因子,属于SOX基因家族的一员,可维持从胚胎期开始机体多种生命活动的正常运转.SOX9表达异常可引起一系列生理紊乱,并与肿瘤的发生密切相关.本文对SOX9在不同生理病理条件下的表达情况,与microRNA的相互作用以及可能参与的潜在的多种调节通路进行综述,以期为SOX9在疾病特别是肿瘤发生发展中的作用研究提供新的信息.
更多SOX9 is an important transcription factor closely related to the sex determination, which belongs to SOX gene family.SOX9 can maintain the normal operation of a variety of life activities from the embryonic stage of the body.However, the ectopic expression of SOX9 can lead to a series of physiological disorders.In this review, we focus on introducing the expression of SOX9 in different physiological and pathological conditions, the interactions between SOX9 and microRNAs and the involved potential pathways.Hopefully, this review provides novel references to further studies on the role of SOX9 in tumorigenesis.
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