细胞型朊蛋白分子结构及其相关疾病的研究进展
Research progress in molecular structure and related diseases of cellular prion protein
细胞型朊蛋白(cellular prion protein,PrPC)是一种高度保守且广泛表达的糖磷脂酰基醇(glycosyl phosphatidyl inositol,GPI)锚定糖蛋白,定位于脂筏.在哺乳动物体内,PrPC在中枢神经系统和网状内皮系统中大量存在,其它组织中有少量分布.目前研究表明,PrPC分子结构具有重要的生理功能之外,还与神经系统疾病和肿瘤发生等相关.本文重点阐述了PrPC的分子结构、组织分布及其相关疾病研究进展.
更多Cellular prion protein (PrPC) is a highly conservative and widely expressed anchored glycoprotein of glycosylphosphatidyl inositol (GPI), located in lipid rafts.In mammals, PrPC is abundantly distributed in the reticuloendothelial system and central nervous system.Current research suggests that the physiological function of PrPC is related to the diseases of central nervous system and carcinogenesis.In this paper, the progress on the structure, tissue distribution and related diseases of PrPC is reviewed.
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