四种清热解毒类中草药对广泛耐药鲍曼不动杆菌的体外抑菌比较

Comparison of in vitro bacteriostatic effects of 4 kinds of heat-clearing and antpyretic-detoxicate drugs against acinetobacter baumannii with extensive drug resistance

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摘要目的探讨板蓝根、鱼腥草、金银花、连翘以及与头孢哌酮/舒巴坦联合对广泛耐药鲍曼不动杆菌的抑菌效果.方法应用微量肉汤稀释法测定4种中草药单用以及与头孢哌酮/舒巴坦联用对30株广泛耐药鲍曼不动杆菌的最低抑菌浓度(minimal inhibitory concentration,MIC),计算部分抑菌浓度(fraction inhibitory concentration,FIC)指数,比较4种中草药单用以及与头孢哌酮/舒巴坦联用的抑菌效果.结果板蓝根的MIC范围是31.2～125mg/mL,鱼腥草的MIC范围是62.5～125 mg/mL,金银花的MIC范围是31.2～62.5 mg/mL,连翘的MIC范围是2.0～31.2 mg/mL;板蓝根与头孢哌酮/舒巴坦联用FIC指数:FIC≤0.5为26.7％,0.5<FIC≤1为40％,1<FIC≤2为33.3％,FIC>2为0％;鱼腥草与头孢哌酮/舒巴坦联用FIC指数:FIC≤0.5为26.7％,0.5<FIC≤1为16.7％,1<FIC≤2为56.7％,FIC>2为0％;金银花与头孢哌酮/舒巴坦联用FIC指数:FIC≤0.5为0％,0.5<FIC≤1为23.3％,1<FIC≤2为56.7％,FIC>2为20％;连翘与头孢哌酮/舒巴坦联用FIC指数:FIC≤0.5为0％,0.5<FIC≤1为3.3％,1<FIC≤2为23.3％,FIC>2为73.3％.结论不同中草药单用以及与头孢哌酮/舒巴坦联合表现出了不同的抑菌效果,连翘单用抑菌效果最好;板蓝根与头孢哌酮/舒巴坦联合抑菌效果最好;连翘与头孢哌酮/舒巴坦体外联合抑菌效果较差.