系统性红斑狼疮诊断标准及治疗进展
Progress of diagnostic criteria and treatment in systemic lupus erythematosus
系统性红斑狼疮(SLE)是一种常见的、复杂的自身免疫性疾病,2009年美国风湿病学会(ACR)年会上 SLE 国际临床协作组提出新的 SLE 分类标准,分为临床标准和免疫学标准2个部分,更强调临床相关性,更重视脏器受累,灵敏度更高,但特异性低于1997年 ACR 标准。Kidney Disease:Improving Global Outcomes (KDIGO)指南和 ACR 指南分别对狼疮性肾炎的治疗原则加以阐述,建议儿童和成人的治疗方案一样,根据体型和肾小球滤过率调整剂量。生物制剂可用于传统免疫抑制剂无效或不能耐受的 SLE,是 SLE 治疗革命性的进展。
更多Systemic lupus erythematosus(SLE)is a common and complicated autoimmune disease. The Sys-temic Lupus International Collaborating Clinics Group undertook a revision of the American College of Rheumatology (ACR)classification criteria for SLE in 2009. The new revision included clinical criteria and immunogic criteria,and had greater sensitivity but lower specificity than ACR - 1997. Kidney Disease:Improving Global Outcomes(KDIGO) clinical practice guideline and ACR guideline elaborated the treatment for lupus nephritis. Children with lupus nephritis should receive the same therapies as adults with dosing based on patient size and glomerular filtration rate. Biological agents could be used to treat refractory SLE or those who were intolerant to traditional immunosuppressant.
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