摘要新生隐球菌容易侵犯中枢神经系统引起严重的隐球菌脑膜炎.隐球菌脑膜炎病死率高,抗真菌药物疗程长、不良反应多,是当今威胁儿童生命的严重感染性疾病.近年来,隐球菌嗜中枢神经系统感染的机制研究取得了长足的进展,隐球菌参与侵袭中枢神经系统的相关毒力因子及宿主细胞应答信号通路相继被发现,在抗真菌治疗的同时进行免疫功能调节治疗已经成为一种重要的辅助手段.现对新生隐球菌脑膜炎的发病机制及免疫治疗的研究现状进行讨论.

abstractsCryptococcus neoformans(CN) is a kind of opportunistic fungal pathogen which has a predilection for the central nervous system,resulting in devastating meningitis.The management of cryptococcal meningitis remains challenging because of its high mortality,the toxicity and uncertainty effect of antifungal therapy.In recent years,the study of the mechanism of neurotropism of CN has made a great progress.Many violence factors of this pathogen and several signal pathways of the host involved in this process have been discovered.Combination therapy with immunotherapy to regular antifungal treatment has become an important adjuvant method.The present review will concisely present current progress of pathogenesis and immunotherapy of cryptococcal meningitis.