间充质干细胞移植治疗新生儿缺氧缺血性脑病研究进展
Research progress of neonatal hypoxic-ischemic encephalopathy treatment with mesenchymal stem cells
新生儿缺氧缺血性脑病(HIE)是新生儿围生期死亡和后期神经发育障碍的重要原因,传统治疗方案对改善预后的效果甚微,亚低温治疗是过去10年中最有效的治疗方法,但临床应用受胎龄、发病时间限制.当前,干细胞移植是治疗HIE新的研究方向,其中间充质干细胞因其取材容易、低免疫源性和潜在神经再生属性等优势在未来临床应用中最具前景.现就间充质干细胞移植治疗新生儿HIE的研究进展进行综述.
更多Neonatal hypoxic-ischemic encephalopathy (HIE) can result in serious outcomes including death during the newborn period and later neuropsychological handicaps.So far,there have been no obvious effect on the improvement of prognosis with traditional treatments,and the cryogenic treatment is the most effective treatment for the past decade,while the clinical application is limited by age and disease course.At present,stem cell transplantation in the treatment of HIE is the new direction,of which the mesenchymal stem cells are outstanding by its easy materials,low immunogenicity and potential nerve regeneration properties.This paper reviews and updates the progress of mesenchymal stem cell transplantation for neonatal HIE.
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