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促性腺激素释放激素类似物在儿童中枢性性早熟中的应用

Application of gonadotropin-releasing hormone analogues in children with central precocious puberty

摘要:

促性腺激素释放激素(GnRH)依赖性性早熟/中枢性性早熟(GDPP/CPP)是儿科内分泌系统的常见病之一,促性腺激素释放激素类似物(GnRHa)是国际上治疗CPP的主要药物,其通过抑制下丘脑-垂体-性腺轴的活动和性激素分泌,减缓CPP患儿骨龄进展、改善成年身高。在临床实践中,仍需要不断探索GnRHa治疗的获益人群,探讨GnRHa的最佳治疗方案,不断完善GnRHa长期疗效和安全性证据。

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abstracts:

Gonadotropin-releasing hormone (GnRH) dependent precocious puberty/central precocious puberty (GDPP/CPP) is one of the common diseases of the pediatric endocrine system.CPP is mainly treated with gonadotropin-releasing hormone analogues (GnRHa) internationally.They slow the progression of bone age and improve adult height in children with CPP by inhibiting the activity of the hypothalamic-pituitary-gonadal axis and the secretion of sex hormones.In clinical practice, the populations who benefit from GnRHa treatment and the best GnRHa treatment plan still need to be investigated, and the long-term efficacy and safety evidence of GnRHa should be further improved.

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作者: 董关萍 傅君芬
栏目名称: 指南解读
DOI: 10.3760/cma.j.cn101070-20200603-00931
发布时间: 2021-04-06
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  • 下载:45

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