淋巴瘤化疗患者症状群的调查及相关因素分析
Symptom clusters in patients with lymphoma receiving chemotherapy
目的 了解淋巴瘤化疗患者的相关症状,探讨其症状群及相关因素.方法 选取2016年9-12月在淋巴瘤科接受化疗的患者111例,应用自行设计一般量表、中文版安德森症状评估量表和美国东部肿瘤协作组(ECOG)体力状态评分3个量表对研究对象进行调查.结果 淋巴瘤化疗患者症状发生率和严重度较高的均为口干、睡眠不安、疲乏,发生率分别为79.3%(88/111)、75.7%(84/111)、73.0%(81/111),严重度分别为2(1~4)、2(1~4)、2(0~5)分,症状困扰对工作和情绪影响最大;探索性因子分析得出三大症状群:睡眠-消化道症状群、疲乏-心理症状群和病感症状群;多元线性回归分析显示,睡眠-消化道症状群的影响因素为性别、化疗次数;疲乏-心理症状群的影响因素为性别、ECOG评分、婚姻;病感症状群的影响因素为化疗次数(t=-2.326~3.917,P<0.05或0.01).结论 淋巴瘤化疗患者相关症状发生率较高,构成了三大症状群,性别、婚姻、ECOG评分、化疗次数为症状群的相关因素,为症状管理提供一定依据.
更多Objective To explore related symptom clusters of patients with lymphoma receiving chemotherapy, and to investigate the categories and influencing factors. Methods From the period of September to December 2016, 111 inpatients with lymphoma receiving chemotherapy were enrolled from the department of lymphoma. Anderson Syptom Assessment Scale Chinese version (MDASI-C), Self-designed general scale and ECOG physical status score were adopted to conduct survey. Results During chemotherapy, the first three syndromes with the highest incidence and most severe were dry mouth, sleep disturbed and fatigue, their incidence rates were 79.3%(88/111), 75.7%(84/111) ,73.0%(81/111), the severity degree was 2(1-4), 2(1-4), 2(0-5). By exploratory factor analysis, three syndrome clusters were found out: sleep-gastrointestinal symptom group, fatigue-psychological symptom group and disease symptom group. Multiple linear regression analysis showed that the influencing factors of the digestive tract symptom group were gender, number of chemotherapy. The fatigue-psychological symptoms were sex, ECOG score, marriage. The disease symptom group was timess of chemotherapy (t=-2.326-3.917, P<0.05 or 0.01). Conclusions The incidence of related syndromes in patients with chemotherapy is high, some constitute syndrome clusters. Gender, marriage, ECOG score, number of chemotherapy are related factors of the syndrome clusters.
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