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细胞因子诱导的杀伤细胞联合白细胞介素2治疗恶性胸腔积液

Treatment of malignant pleural effusion by cytokine-induced killer cells combined with interleukin-2

摘要:

目的 观察应用细胞因子诱导的杀伤(CIK)细胞联合白细胞介素2(IL-2)治疗恶性胸腔积液的疗效.方法 收集2009年7月至2013年7月于本院肿瘤科就诊的恶性胸腔积液患者50例,随机数字表法分为治疗组(n=24)和对照组(n=26).胸腔积液引流净后,治疗组胸腔灌注CIK细胞联合IL-2,连续3d;对照组灌注IL-2联合顺铂,隔日1次,连续3次.治疗4周后评价疗效和不良反应.结果 治疗组有效率87.50%(21/24),完全缓解率54.17%(13/24);对照组有效率57.69%(15/26),完全缓解率42.31%(11/26).与对照组比较,治疗组的完全缓解率、有效率均增加(均P<0.05).不良反应比较显示,治疗组发热的发生率较高,而对照组胸痛、胃肠道反应、骨髓抑制的发生率较高(均P< 0.05).与治疗前比较,治疗后两组患者的Karnofsky评分均增加(均P<0.05).结论 CIK细胞联合IL-2胸腔灌注治疗恶性胸腔积液不良反应小,疗效确切.

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Objective To observe the efficacy of malignant pleural effusion treated by cytokine-induced killer (CIK) cells combined with interleukin-2 (IL-2).Methods Fifty patients with malignant pleural effusion in oncology clinic of our hospital from July 2009 to July 2013 were recruited and divided into treatment group (n=24) and control group (n=26) by random number table.After pleura1 puncture and drainage,the treatment group were treated with interpleural injection of CIK cells and IL-2 for 3 days continuously,while the control group were treated with interpleural injection of IL-2 and cisplatin for 3 times in every other day.The efficacy and adverse effects were evaluated at 4 weeks after treatment.Results The effective rate and complete remission rate in treatment group were 87.50% (21/24) and 54.17% (13/24),while those in control group were 57.69% (15/26) and 42.31% (11/26).Compared with control group,the complete remission rate and the effective rate increased in treatment group (both P < 0.05).Comparison of adverse effects showed a higher incidence of fever in treatment group,and higher incidence of chest pain,gastrointestinal reactions and myelosuppression in the control group (all P<0.05).As compared with pretreatment,the Karnofsky scores of patients in both groups increased after treatment (both P<0.05).Conclusion The therapy of malignant pleural effusion treated by interpleural injection of CIK cells combined with IL-2 shows a reliable efficacy and less adverse effects.

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