关于脓毒症3.0的争议
Controversies of Sepsis-3
感染诱发的脓毒症是ICU最常见的疾病之一.为了统一认识,利于早期诊断和治疗,降低重症感染的病死率,1991年首次提出了脓毒症的概念.近20余年,伴随脓毒症病理生理研究的深入,其定义和诊断标准也不断更新和完善.2016年,欧洲危重病学会指定专家组重新修订了脓毒症的定义和诊断标准,即脓毒症3.0,主要强调感染导致宿主内环境稳态失衡、潜在致命性风险的器官功能障碍.每次更新都融入许多新的理论或观点,同时也充满了争议.本文主要介绍脓毒症的定义和诊断标准,以及脓毒症3.0存在的争议.
更多Sepsis caused by infection is one of the most common diseases in ICU.In 1991,the concept of sepsis was first put forward for the purpose of unifying cognition,early diagnosis and treatment,and reducing the fatality rate of severe infection.Over the past 20 years,with the development of the septic pathophysiology,its definition and clinical criteria have been constantly updated and improved.In 2016,a task force convened by European Society of Intensive Care Medicine and the Society of Critical Care Medicine revised the definition and clinical criteria of sepsis,namely,Sepsis-3.It mainly emphasizes infection leading to homeostasis disequilibrium,and organ dysfunction with potentially fatal risk.The definition is updated each time;many new theories or ideas are incorporated,and are also some controversies.This review focused on the definition and clinical criteria of sepsis,and the controversies of Sepsis-3.
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