儿童脓毒症诊断标志物的临床应用
The clinical application of biomarkers in pediatric sepsis
脓毒症是导致儿童死亡的重要原因之一,其本质是感染引起的宿主反应失调进而导致的危及生命的器官功能障碍.对于脓毒症,早期诊断非常重要.生物标记物(降钙素原、C-反应蛋白、炎症因子、白细胞计数、中性粒细胞计数、形态及CD64等)可以帮助我们早期识别是由感染还是非感染引起的全身炎症反应,动态监测这些生物标记物,可以有效地评估病情严重程度、预后及疗效.
更多Sepsis is still a leading cause of death in infants and children.It is the result of multiple organ dysfunction syndrome caused by infection.For sepsis,early diagnosis is very important.Biomarkers (procalcitonin,C-reactive protein,pro-inflammatory cytokines,white blood cell count,neutrophil count,left shift and CD64) during the response to infection can be used for early diagnosis.In addition,continuously monitoring these biomarkers can be used for evaluating severity of illness,monitoring of treatment responses and predicting outcome.
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