血小板升高与胃癌预后的关系
Correlation between thrombocytosis and the progress of gastric cancer
目的 探讨血小板升高与胃癌预后的关系.方法 回顾性分析2002年8月至2004年1月天津医科大学肿瘤医院收治的276例胃癌患者的临床资料,术前血小板正常201例,血小板升高75例.采用χ~2检验确定血小板升高的相关因素,通过Cox回归模型,最终确立影响胃癌预后的独立因素.Kaplan-Meier法计算累积生存率,Log-rank检验进行比较.结果 血小板正常的胃癌患者1、3、5年生存率分别为82.4%、50.5%、41.9%,血小板升高的胃癌患者1、3、5年生存率分别为74.7%、37.3%、25.3%.两者5年生存率比较差异有统计学意义(χ~2=7.358,P<0.05);血小板升高与胃癌浸润深度、远处转移、TNM分期、肿瘤直径有关(χ~2=6.946,5.625,14.925,4.028,P<0.05).多因素分析显示血小板升高不是胃癌预后的独立因素.结论 血小板升高与胃癌多种临床病理因素相关,与肿瘤进展及预后相关.
更多Objective To investigate the correlation between thrombocytosis and the progress of gastric cancer. Methods The clinical data of 276 gastric cancer patients who had been admitted to Tianjin Cancer Hospital from August 2002 to January 2004 were retrospectively analyzed. Of all patients, 75 were with thrombocy-tosis and 201 were with normal level of platelet. Data were analyzed by chi-square test, and the prognostie factors for gastric cancer were analyzed by Cox regression model. The accumulative survival was determined by Kaplan-Meier method, and the difference in survival between patients with and without thrombocytosis was analyzed by Log-rank test. Results The 1-, 3-, 5-year survival rates of gastric cancer patients with normal level of platelet were 82.4%, 50.5% and 41.9%, and the 1-, 3-, 5-year survival rates of gastric cancer patients with thrombocy-tosis were 74.7%, 37.3% and 25.3%. There was a significant difference in 5-year survival rates between patients with or without thrombocytosis (χ~2= 7.358, P<0.05). Thrombocytosis was correlated with the depth of invasion, distal metastasis, TNM staging and the tumor size (χ~2=6.946, 5.625, 14. 925, 4.028, P<0.05). The result of multivariate analysis indicated that the content of platelet was not the independent factor of good prog-nosis in gastric cancer. Conclusions There is a close relationship between thromboeytosis and clinieopathological factors of gastric cancer. Thrombocytosis may be used as a reference indicator for the prognosis of gastric cancer.
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