• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

食管癌18氟-氟代脱氧葡萄糖PET/CT检查特征

Imaging characteristics of Fluorine-18-fluorodeoxyglucose PET/CT examination in esophageal carcinoma

摘要:

目的 总结食管癌18氟-氟代脱氧葡萄糖(18 F-FDG) PET/CT检查影像学特征,以及代谢参数与分期的关系.方法 回顾性分析2012年1月至2014年12月第二军医大学附属长海医院收治的53例食管癌患者的临床资料.患者行全身18 F-FDG PET/CT检查.分析PET/CT检查图像特征,并以SUV 2.5为阈值,获得食管原发病灶的最大标准摄取值(SUVmax)、平均标准摄取值(SUVavg)、肿瘤代谢体积(MTV)、最大直径,计算病灶糖酵解总量(TLG);同时测量转移区域淋巴结和远处转移癌的SUVmax.正态分布的计量资料以(x)±s表示,组间比较采用独立样本t检验.偏态分布的计量资料以中位数M(Qn)表示,组间比较采用Mann-Whitney检验.结果 (1)肿瘤部位和体积:肿瘤位于食管颈段1例,胸上段16例,胸中段18例,胸下段13例,同时位于胸上段+胸中段2例,胸中段+胸下段3例.肿瘤体积:1.6 cm× 1.2 cm×2.2cm~6.5 cm×7.0cm×7.2 cm.肿瘤最大直径为(6.1 ±2.1)cm(2.5 ~11.2 cm).(2)PET/CT检查表现:食管原发病灶:96.2% (51/53)的患者食管局限性18 F-FDG摄取值增高,伴管壁增厚;病灶与正常食管壁分界不清;病变段管腔狭窄.3.8% (2/53)的患者食管局部结节样18 F-FDG摄取值增高,CT检查图像示管壁未见增厚.邻近结构:24.5% (13/53)的患者肿瘤侵犯周围组织器官.受侵犯组织器官18F-FDG摄取值增高,与食管原发病灶分界不清.区域淋巴结:77.4% (41/53)的患者发生区域淋巴结转移.转移淋巴结1s F-FDG摄取值增高.远处转移:26.4%(14/53)的患者发生远处转移,主要位于肝和肺.转移癌18 F-FDG摄取值增高.(3)PET/CT检查代谢参数值:53例食管原发灶:肿瘤SUVmax为16.3 ±6.2(4.9~30.9),SUVavg为6.0 ±1.7(3.3 ~10.4),MTV为18.14 cm3 (7.74 cm3 ,28.89 cm3) ,TLG为105.37 g(42.85 g,205.62 g).转移区域淋巴结:SUVmax为10.5 ±5.6(2.7 ~21.9).远处转移癌:SUVmax为13.0±7.1(5.8 ~23.5).(4)不同N、M分期的肿瘤代谢参数比较:N1 ~3期、N0期食管原发病灶的SUVmax分别为16.7±5.9、15.1 ±7.4,MTV分别为20.92 cm3(12.65 cm3,35.73 cm3)、6.88 cm3 (4.40 cm3,21.53 cm3),TLG分别为132.87 g(65.49 g,226.67 g)、35.45 g(17.53 g,124.23 g).N1~3期与N0期食管原发病灶的SUVmax比较,差异无统计学意义(t=-0.785,P>0.05).N1 ~3期食管原发病灶的MTV、TLG高于N0期,两者比较,差异均有统计学意义(Z=-2.657,-2.614,P<0.05).M1期、M0期食管原发病灶的SUVmax分别为16.9±7.4、16.1 ±5.8,MTV分别为16.14 cm3 (8.33 cm3,26.69 cm3)、20.08 cm3 (7.50 cm3,31.34 cm3),TLG分别为97.77 g(51.15 g,153.50 g)、106.01 g(40.16 g,214.55 g).M0期和M1期食管原发病灶的SUVmax、MTV、TLG间比较,差异均无统计学意义(t=0.387,Z=-0.282,-0.383,P>0.05).结论 食管癌18F-FDG PET/CT检查主要表现为食管局限性18F-FDG摄取值增高伴管壁增厚,常见于胸中段,且不同N分期的食管原发病灶,MTV、TLG不同.PET/CT检查对显示食管原发病灶和转移癌具有一定临床价值.

更多
abstracts:

Objective To summarize the imaging characteristics ship of Fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT examination in esophageal carcinoma and the relation between metabolic parameters and stage.Methods The clinical data of 53 patients with esophageal carcinoma who were admitted to the Changhai Hospital Affiliated to the Second Military Medical University between January 2012 and December 2014 were retrospectively analyzed.All the patients underwent 18F-FDG PET/CT examination.The standardized uptake value 2.5 (SUV 2.5) was set as threshold value, and maximum SUV (SUVmax), average SUV (SUVavg), metabolic tumor volume (MTV) and maximum diameter of primary lesion were collected.The total lesion glycolysis (TLG) was calculated and SUVmax of lymph nodes in the metastasis area and distant metastasis carcinoma was measured.Measurement data with normal distribution were presented as (x) ± s, and comparison between groups was evaluated with an independent sample the t test.Skew distribution data were described as M(Qn), and comparison between groups was analyzed using the Mann-Whitney test.Results (1) Tumor location and volume: one tumor was located at the cervical portion of the esophagus, 16 at the upper thoracic portion, 18 at the mid-thoracic portion,13 at the lower thoracic portion, 2 at the upper thoracic portion and mid-thoracic portion and 3 at the mid-thoracic portion and the lower thoracic portion.Tumor volume was 1.6 cm × 1.2 cm × 2.2 cm-6.5 cm × 7.0 cm× 7.2 cm and maximum diameter of tumor was (6.1 ± 2.1) cm (range, 2.5-11.2 cm).(2) Performance of PET/CT examination: of 53 patients, 51 (96.2%) had 18 F-FDG uptake increased, thickening esophageal wall, unclear boundary between lesions and normal tissues and luminal stenosis of the lesion, and 2 (3.8%) had local nodular 18F-FDG uptake increased without thickening esophageal wall.The infringement of the surrounding tissue organs was detected in 13 patients (24.5%), with unclear boundary between lesions with primary esophageal tumors and 18F-FDG uptake increased.The regional lymph nodes metastasis was detected in 41 patients (77.4%), with 18F-FDG uptake increased.The distal metastasis of 14 patients (26.4%) was located in the liver and lung, with 18 F-FDG uptake increased.(3) Metabolic parameters of PET/CT examination : SUVmax, SUVavg, MTV and TLG in the primary esophageal lesion of 53 patients were 16.3 ±6.2 (range, 4.9-30.9) , 6.0 ± 1.7 (range, 3.3-10.4), 18.14 cm3 (7.74 cm3, 28.89 cm3) and 105.37 g (42.85 g, 205.62 g), respectively.SUVmax of regional lymph nodes metastasis and distant metastasis tumors were 10.5 ±5.6 (range, 2.7-21.9) and 13.0 ± 7.1 (range, 5.8-23.5).(4) Comparisons of metabolic parameters of tumors in different N, M stages : SUVmax, MTV and TLG were 16.7 ±5.9, 20.92 cm3 (12.65 cm3, 35.73 cm3) and 132.87 g (65.49 g, 226.67 g) inthe N1-3 stage and 15.1 ±7.4, 6.88 cm3(4.40 cm3, 21.53 cm3) and 35.45 g (17.53 g, 124.23 g) in the N0 stage, respectively, with no significant difference in the SUVmax between the N1-3 stage and N0 stage(t =-0.785, P > 0.05).MTV and TLG of the primary esophageal lesion in the N1-3 stage were significantly higher than that in the N0 stage (Z =-2.657,-2.614, P < 0.05).SUVmax, MTV and TLG of the primary esophageal lesion were 16.9 ± 7.4, 16.14 cm3 (8.33 cm3, 26.69 cm3) and 97.77 g (51.15 g, 153.50 g) in the M1 stage,16.1 ±5.8,20.08 cm3 (7.50 cm3, 31.34 cm3) and 106.01 g (40.16 g, 214.55 g) in the M0 stage,respectively, showing no significant difference between the M1 stage and M0 stage (t =0.387, Z =-0.282,-0.383, P > 0.05).Conclusions Imaging characteristics of 18 F-FDG PET/CT examination for esophageal carcinoma include the increase of 18 F-FDG uptake and local or extensive tube wall thickening, and N stage of primary esophageal lesion commonly located in the mid-thoracic portion is related to MTV and TLG.PET/CT examination shows a certain value to the primary and metastatic lesions of the esophagus.

More
作者: 王玉涛 [1] 汪建华 [1] 张建 [2] 孙高峰 [3] 程超 [3] 王涛 [3] 杨剑 [3] 潘桂霞 [3] 邓生德 [1]
期刊: 《中华消化外科杂志》2015年14卷12期 1047-1052页 ISTICPKUCSCD
栏目名称: 影像集锦
DOI: 10.3760/cma.j.issn.1673-9752.2015.12.015
发布时间: 2016-01-08
基金项目:
上海市博士后科研资助计划面上项目 上海市卫生局科研项目 浙江省医药卫生科技计划项目
  • 浏览:289
  • 下载:164

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷