摘要目的 探讨成人弱视眼黄斑部视网膜厚度与正常眼的差异.方法 使用光学相干断层成像技术分别对弱视眼组(47例,65眼)与正常眼组(35例,70眼)黄斑区进行水平和垂直扫描,测定黄斑中心小凹和距离中心小凹鼻侧、上方、颞侧、下方700 μm的中心凹区及1000 μm黄斑旁中心凹区的视网膜厚度,所得数据进行t检验分析.结果 弱视眼组黄斑中心小凹及距离中心小凹鼻侧、上方、颞侧、下方700 μm视网膜厚度分别为(153.45±12.37)μm、(257.68±12.73)μm、(263.27±15.17)μm、(247.55±13.62)μm、(262.41±16.37)μm,正常眼组相应位置的视网膜厚度分别为(142.27±9.61)μm、(251.39±16.29)μm、(254.92±13.83)μm、(240.27±14.54)μm、(256.71±15.81)μm,弱视眼视网膜厚度较正常眼大,差异均有统计学意义(t=5.39、2.49、3.34、2.99、2.05,P<0.05);弱视眼距离中心小凹鼻侧、上方、颞侧、下方1000 μm视网膜厚度分别为(262.09±13.67)μm、(266.46±12.76)μm、(252.11±13.47)μm、(264.32±15.23)μm,正常眼组相应位置的视网膜厚度分别为(264.25±14.42)μm、(269.61±13.66)μm、(250.91±13.27)μm、(261.75±14.18)μm,两组相比差异无统计学意义(t=0.89、1.38、0.52、1.06,P>0.05).结论 弱视患者的黄斑中心小凹及中心凹处视网膜较正常服厚,弱视的发生可能与黄斑中心小凹及中心凹处视网膜异常有关.

abstractsObjective To investigate the retinal thickness of the macula in adult amblyopic and normal eyes with optical coherence tomography (OCT). Methods The eyes of 47 amblyopic patients (65 eyes total)and 35 normal people (70 eyes total) were examined horizontally and vertically with OCT. The mean thickness of the retinal foveola was measured. 700 μm and 1000 μm to the foveola was measured in the nasal, superior, temporal and inferior quadrants. The data were analyzed by the SPSS 10.0 software, using t test. Results The mean retinal thickness of the foveola and 700 μm away from the foveola in amblyopic eyes were (153.45±12.37)μm, (257.68±12.73)μm, (263.27±15.17)μm, (247.55±13.62)μm and (262.41±16.37)μm, respectively. The retinal thickness of corresponding positions in normal eyes was (142.27±9.61)μm, (251.39±16.29)μm, (254.92±13.83)μm, (240.27±14.54)μm and (256.71±15.81)μm, respectively. The mean retinal thickness of the foveola and 700 μm from the foveola in amblyopic eyes was significantly larger than that in normal eyes (t= 5.39, 2.49, 3.34, 2.99, 2.05, respectively. P<0.05). The mean retinal thickness of the foveola and 1000 μm from the foveola in amblyopic eyes were (262.09±13.67)μm, (266.46±12.76)μm, (252.11± 13.47)μm and (264.32±15.23)μm, respectively. The retinal thickness of the corresponding positions in normal eyes was (264.25±14.42)μm, (269.61 ±13.66)μm, (250.91 ±13.27)μm and (261.75±14.18)μm, respectively. There was no significant difference in the perimacular (1000 μm from the foveola) retinal thickness between amblyopic and normal eyes (t=0.89, 1.38, 0.52, 1.06, respectively. P>0.05). Conclusion Retinal thicknesses of the foveola and 700 μm from the foveola in amblyopic eyes are thicker than those in normal eyes. The retinal abnormality of the foveola and fovea may be related to amblyopia.