检索历史 清除

目的 探讨环氧合酶-2(COX-2)在子宫内膜病变发生发展中的作用.方法 用免疫组织化学法检测各组标本中COX-2的表达情况,并比较同组不同期别、不同病理分级及不同组别内膜癌COX-2表达的差异.结果 COX-2的表达在子宫内膜癌Ⅲ期与其他期别之间的差异有统计学意义(P<0.05);COX-2在子宫内膜癌组、增生过长组和正常内膜之间表达存在差异,两两比较,差异有统计学意义(P<0.05);COX-2在子宫内膜癌不同病理分级间比较差异无统计学意义(P>0.05);COX-2在简单型增生过长和复杂型增生过长之间的表达存在差异(P<0.05).结论 COX-2在子宫内膜病变发生发展中起到重要作用,COX-2抑制剂用于子宫内膜癌术后辅助治疗或失去手术时机的患者具有可行性.

Objective To study the role of cyclcoxygenase-2 in the growth and development of the endome-trial lesions. Methods The expression of cycloogxygenase-2 (COX-2) were tested by immunohistocbemistry. Compar-ison of endometrial cancer COX-2 expression was made within each group at different stages,for different pathological classification. Another groups comparison of COX-2 expression was made. Results ( 1 ) COX-2 in endometrial cancer in the different expression of other differences and differences were significant ( P<0.05 ). Ⅲ mainly for the period between the stage and the other had a significant difference( P<0.05 ). (2) COX-2 in endometrial cancer,hyperplasia and normal expression of the differences between endometriosis, the difference was significant ( P<0.05 ). (3)COX-2 in endometrium cancer different pathology graduation difference:G1(high idiophase) < G2(idiophase) < G3(low id-iophase), but does not have the difference after the comparison in statistics ( P>0.05 ). (4) The expression of COX-2 in simple hyperplasia and complex hyperplasia was statistically significant different ( P<0.05 ). Conclusion That COX-2 in the development of endometrial lesions play an important role, it could be inferred of COX-2 inhibitors for endometrial cancer treatment or treatment of postoperative the timing of the loss surgery patients is feasible.