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目的 观察大黄素温敏凝胶治疗慢性牙周炎的临床疗效及安全性. 方法 选取40例慢性牙周炎患者采用同一口腔内病情相同牙齿的自身对照研究设计,分成观察组40个牙和对照组40个牙,观察两组治疗前后各阶段各项临床指标的变化情况. 结果 观察组和对照组在治疗前各项临床指标差异均无统计学意义(均P＞0.05);在治疗后第6周时,两组PLI、SBI、PD、AL、MD与治疗前比较均有显著改善(t=39.06、62.76、20.50、8.05、158.32、31.45、46.53、8.43、8.08、8.03,均P＜0.01),而观察组较对照组改善更为明显(t=31.50、27.91、3.92、7.38、20.09,均P＜0.01);在治疗后第12周时,两组PLI均有所反弹,但与治疗后6周时差异无统计学意义(P＞0.05),观察组与对照组之间差异有统计学意义(t=23.39,P＜0.01);治疗后第12周时观察组SBI、PD、AL、MD较治疗后第6周时有明显改善(t=3.50、21.18、9.93、9.05,均P＜0.01),与对照组差异均有统计学意义(t=30.69、5.76、13.41、25.60,均P＜0.01). 结论 大黄素温敏凝胶可以有效控制慢性牙周炎引起的各种临床症状.

Objective To evaluate the clinical effects of scaling and root planning combined with application of the emodin thermosensitive hydrogel on periodontitis. Methods Forty patients with chronic periodontitis with a total of eighty teeth were included in the study.For each patient after scaling and root planning,the teeth on one side were assigned as the test group and treated with the emodin thermosensitive hydrogel in the pocket once a week for four weeks.The teeth on the other side were assigned as the control group.All the clinical parameters were recorded at the baseline,the 6th week and 12th week after the treatment. Results At the baseline,there was no difference in the clinical parameters between the test group and the control group(P＞0.05).A statistically significant improvement of all clinical parameters was observed in both groups 6w later(t = 39.06、62.76、20.50、8.05、158.32、31.45、46.53、8.43、8.08、8.03)(P＜0.01＝,and all clinical parameters of the test group were better than those of the control group,the differences were statistically significant(t = 31.50、27.91、3.92、7.38、20.09)(P＜0.01＝. Conclusion The emodin thermosensitive hydrogel could effectively control the symptoms of periodontitis.