子宫内膜癌组织中缺氧诱导因子-1α、血管内皮生长因子基因表达的临床意义
Clinical significance of the expression of HIF-1α and VEGF gene in endometrial carcinoma tissue
目的 探讨HIF-1α、VEGF基因表达与子宫内膜癌临床分期间关系.方法 对30例子宫内膜癌患者的癌组织应用免疫组织化学方法进行HlF-1α、VEGF的检测,分析不同的病理分型和临床分期的表达情况.另取同期存档的子宫内膜不典型增生组织蜡块10例作为对照.结果 H1F-1α、VEGF在子宫内膜不典型增生及子宫内膜癌各期的阳性表达率差异均有统计学意义(x2=11.87、8.71,均P<0.05);超声肿瘤血流分级与HIF-α、VEGF间存在相关性.病变与HIF-1α、VEGF间存在相关性.结论 HIF-α、VEGF表达程度与子宫内膜癌恶性程度呈正相关.HIF-1α、VEGF子宫内膜癌的预后和转移关系密切.
更多Objective To explore the relationship between the expression of HIF-1 alpha,VEGF gene and cliulcal stage of endometrial cancer. Methods 30 patients with the membrane carcinoma were detected VEGF, HIF-1α expression by immunohistochemical method. The expression of different pathological type and clinical stage were analyzed. Another 10 pieces achieved from endometriosis dysplasia organization were taken as control. Results The positive rate of HIF-1 alpha, VEGF in endometriosis dysplasia and endometrial carcinoma were statistically significant differences( x2=11.87,8. 71, all P < 0. 05 );There was correlated relationship between ultrasonic grading of tumor blood and HIF-1 alpha, VEGF; There was correlated relationship between Lesions and HIF-1 alpha, VEGF.Conclusion The expressions of HIF-1 alpha, VEGF were positively correlated to the degree,metastasis and prognosis of malignant endometrial carcinoma.
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