狼疮肾炎患者血清自身抗体检测及意义
Clinical significance of autoimmune antibody in patients with lupus nephritis
目的 探讨狼疮肾炎(LN)患者血清自身抗体检测的临床意义.方法 检测60例系统性红斑狼疮(SLE)患者血清抗Clq抗体、ANA抗体、抗dsDNA、核小体、抗-Sm抗体,并依据有无狼疮肾炎分为狼疮肾炎组(A组)38例和无狼疮肾炎的SLE对照组(B组)22例.结果 A组抗C1q、dsDNA、核小体、抗-Sm和ANA抗体阳性率显著高于B组(均P<0.01),血清中抗C1q抗体水平分别与SLEDAI评分、抗ANA水平呈显著正相关(均P<0.01);与补体C3、C4含量呈显著负相关(P<0.01).结论 抗C1q抗体、dsDNA、核小体和ANA是反映SLE患者并发肾脏损害的重要指标,在LN诊断和判定活动性方面有重要作用.
更多Objective To investigate the clinical significance autoimmune antibody in patients with lupus nephritis(LN).Methods ELISA assay was performed to examine anti-C1q antibody and anti-nucleus antibody;immunoblot assay was performed to examine anti-dsDNA antibody,anti-nucleosome antibody and anti-Sm antibody in sera of 38 patients with LN and 22 patients of system lupus erythemalosus without renal damage.Standard methods were uaed for laboratory testing.Results The positive rate of anti-C1q antibody,anti-dsDNA antibody,anti-nucleosome antibody,anti-Sm antibody and anti-nucleus antibody were significantly higher in LN than in controls(P<0.01).AntiC1q antibody and anti-nucleus antibody were significantty higher in LN than in controls(P<0.01,P<0.05).Serum levels of anti-C1q antibody was positively correlated with SLEDAI score and the level of anti-nucleus antibody,but was negatively oorrelated with C3、 C4.Conclusion Anti-C1q antibody,anti-dsDNA antibody,anti-nucleosome antibody and anti-nucleus antibody are suggested to play a role in the pathogenesis of LN and can be used as diagnostic tools and disease activity markers.
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