氯吡格雷对不稳定型心绞痛患者血浆内皮素和降钙素基因相关肽的影响
Effect of Clopidogrel on Plasma Endothelin and Calcitonin Gene Related Peptide in Patients with Unstable Angina Pectoris
目的 探讨氯吡格雷对不稳定型心绞痛(UAP)患者血浆内皮素和降钙素基因相关肽的影响.方法 将100例UAP患者随机分为两组,分别用消心痛(50例)及氯吡格雷加消心痛(50例)联合治疗,采用放免法观察治疗前后患者血浆内皮素(ET)及降钙素基因相关肽(CGRP)含量,另选20名健康体检者作对照.结果 与健康志愿者相比,UAP患者血浆ET含量明显升高(P<0.05),CGRP明显降低(P<0.05).较消心痛治疗组相比,联合使用氯吡格雷治疗后患者ET明显下降(P<0.01),CGRP明显升高(P<0.05).结论 氯吡格雷能显著改善ET、CGRP代谢失衡状况,是治疗UAP的有效药物.
更多Objective To investigate the effect of Clopidogrel on the plasma endothelin(ET)and calcitonin gene related peptide(CGRP)in patients with unstable angina pectoris(UAP).Methods Patients with UAP were divided into two groups,the regular treated group(n =50)was treated with Isoket and the Dansben group(n =50)was treated with combined Isoket and Clopidogrel.The plasma ET and CGRP were measured before and after treatment by radioimmunoreactive assay.Data were compared between the two groups and also compared with those measured in 20healthy subjects for control.Results ET level was significantly higher and CGRP level was lower in UAP patients than that in healthy subjects(P < 0.05).After Clopidogrel treatment,ET was significantly decreased(P < 0.01)and CGRP increased(P <0.05)in combined treatment group compared with patients received lsoket only.Conclusion Clopidogrel was an effective drug for UAP treatment,which could efficiently regulate the ET and CGRP metabolism.
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