川崎病患儿血清白细胞介素-6、-10、-1水平变化及意义
Changes of serum IL-6, IL-10 and IL-1 in patients with Kawasaki disease and its clinical significance
目的 观察川崎病患儿血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-1(IL-1)水平变化及其临床意义.方法 选取38例川崎病患儿(观察组)和38例健康儿童(对照组)血清IL-6、IL-10和IL-1水平,观察两组差异及对治疗效果的影响.结果 观察组IL-6、IL-10和IL-1水平均高于对照组(t=10.3877、15.1010、15.1243,均P<0.05),观察组急性期IL-6、IL-10、IL-1等水平明显高于亚急性期患儿(t=9.7594、11.6486、11.6622,均P<0.05)及对照组(t=11.7032、11.7718、11.8267,均P<0.05).对照组48 h内细胞凋亡率为(2.8±0.8)%,明显低于川崎病患儿的(38.3±7.9)%(t=38.59,P<0.01).血小板升高[(464.0±110.2)×109/L]的川崎病患儿IL-1水平(663±94) ng/L,明显高于无血小板升高[(307.0±104.9)×109/L]的患儿(492±92) ng/L(t =13.1044,P<0.05).结论 检测川崎病患儿血清IL-6、IL-10和IL-1水平,有助于临床判断的病情、并发症情况及治疗效果,具有重要的临床意义.
更多Objective To observe the serum levels of IL-6,IL-10 and IL-1 in children with Kawasaki disease and its clinical significance.Methods 38 childrey with of Kawasaki disease were selected as observction group,then selected 38 cases of normal children as control group.Serum IL-6,IL-10 and IL-1 levels were observed two groups.Results Observation group IL-6,IL-10 and IL-1 levels were higher(t =10.3877,15.1010,15.1243,all P<0.05),acute phase of observation group IL-6,IL-10,IL-1,etc.levels were significantly higher than the sub-acute phase patients ( t =9.7594,11.6486,11.6622,all P < 0.05 ) and control group ( t =11.7032,11.7718,11.8267,all P <0.05 ).48h apoptosis rate in the control group( 2.8 ± 0.8 )% was significantly lower than in children with Kawasaki disease(38.3 ±7.9)% (t =38.59,P <0.01 ).Platelets increased[ (464.0 ± 110.2) × 109/L] of the IL-1 level in children with Kawasaki disease(663 ±94)ng/L was significantly higher than those without elevated platelet [ (307.0 ±104.9) × 109 /L ] of children( 492 ± 92 ) ng/L ( t =13.1044,P < 0.05 ).Conclusion Thedetection of serum IL-6,IL-10 and IL-1 levels may aid clinical diagnosis of the condition of children with Kawasaki disease,complications and treatment,have important clinical significance.
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