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目的 探讨血清降钙素原(PCT)检测在新生儿感染性疾病早期诊断的临床应用价值.方法 疑似感染患儿50例,入院时、入院第5天检测血清PCT、CRP值、血常规、血培养.并根据临床表现和检验结果将50例患儿分别分为细菌感染组32例和非细菌感染组18例,并进行PCT、CRP、血常规、血培养值比较.结果 细菌感染组入院时血清PCT值≥2μg/L 27例,WBC升高6例,CRP阳性7例,血培养(3 d)阳性4例,非细菌感染组入院时血清PCT值≥2 μg/L 2例、WBC升高2例,CRP阳性3例,血培养(3 d)阳性1例；入院第5天细菌感染组血清PCT值≥2 μg/L 23例、WBC升高15例,CRP阳性6例,血培养(5 d)阳性9例,非细菌感染组入院时血清PCT值≥2μg/L 1例、WBC升高3例,CRP阳性4例,血培养(5 d)阳性1例.两组入院时WBC,CRP,血培养阳性例数比较,X2值分别是0.50,0.19,0.62,均P＞0.05,差异无统计学意义,但PCT值:x2=25.30,P＜0.05,差异有统计学意义.入院第五天两组CRP阳性例数比较:x2=0.83,P＞0.05,差异无统计学意义,但PCT,WBC,血培养比较:x2 =20.30、4.39、8.56,均P＜0.05,差异有统计学意义.结论 血清PCT检测可作为新生儿早期感染的重要诊断指标,其敏感度和特异度均优于,血常规及血培养.

Objective To explore the clinical application value of serum procalcitonin (PCT) detection in diagnosis of neonatal infection disease.Methods The serum PCT,CRP values,routine blood test,blood cultures of 50 children with suspected infection was detected at admission and five days after admission.According to the clinical manifestations and the test results,50 children were divided into the bacterial infection group (32 cases) of and non-bacterial infection group (18 cases),and the value of PCT,CRP,routine blood test,blood culture was compared.Results Of bacterial infection group at admission,the serum PCT values in 27 cases were more than or equal with 2μg/L,white blood cell (WBC) increased in 6 cases,CRP of 7 cases were positive,blood cultures (3d) of 4 cases were positive,and of non-bacterial infection group at admission,the serum PCT value in 2 cases were more than or equal with 2μg/L,WBC increased in 2 cases,blood cultures (3d) of 1 case was positive ; Of bacterial infection group 5 days after admission,the serum PCT value in 23 cases were more than or equal with 2μg/L,WBC increased in 15 cases,CRP of 6 cases were positive,blood culture (5d) of 9 case were positive,and of non-bacterial infection group 5 days after admission,the serum PCT value in 1 cases was more than or equal with 2μg/L,WBC increased in 3 cases,CRP of 4 cases were positive,blood culture (5d) of 1 case was positive.At admission the cases of WBC increasing,CRP positive,blood culture positive of the two groups had no statistically significant differences (x2 =0.50,0.19,0.62,all P ＞ 0.05),but the cases of the PCT value which was more than or equal with 2μg/L had statistically significant differences between the two groups (x2 =25.30,P ＜ 0.05).5 days after admission the cases of WBC increasing,PCT,blood culture positive of the two groups had no statistically significant differences (x2 =4.39,20.30,8.56,all P ＜ 0.05),but the cases of the CRP value significant differences between the two groups (x2 =0.83,P ＞ 0.05).Conclusion The detection of serum PCT can be used as an important index of diagnosis for early neonatal infections,and its sensitivity and specificity are better than,blood routine and blood culture.