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儿童功能性胃肠病与食物过敏关系的研究

Study on the relationship between children's functional gastrointestinal disease and food allergy

摘要:

目的 探讨儿童功能性胃肠病与食物过敏的关系及近期预后.方法 选取108例功能性胃肠病患儿作为观察组,健康儿童36例为对照组.采用ELISA法对10种过敏食物进行IgG抗体浓度水平及血清总IgE水平进行检测,采用不同方法对患者进行健康饮食指导,3~6个月后比较两组的症状改善情况.结果 观察组1 ~10种不等的食物过敏原特异性IgG升高的患儿有90例,占83.3%,而对照组有9例,仅占25.0%(x2=20.87,P<0.05).观察组中敏感性最高的是牛奶、蛋清/黄,分别为84例(77.8%)和60例(55.6%).两组比较,均P<0.05.观察组与对照组血清总IgE水平比较,P>0.05.经饮食指导后17例(15.7%)在1个月内症状有所改善,13例(12.1%)在3个月内症状改善21例(19.4%)患者症状在3个月后无改善.总有效率为80.6%.结论 功能性胃肠病患儿易发生食物过敏且以多种食物过敏为主,IgG抗体水平的检测能够正确反应两者的关系,合理饮食结构可改善功能性胃肠病症状.

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Objective To study the relationship between the functional gastrointestinal disease of children and food allergies,and recent prognosis.Methods 108 children with functional gastrointestinal disease were selected as the observation group,at the same time 36 healthy cases were selected as control group.ELISA was used to detect IgG antibody concentration and total IgE level in ten kinds of allergy food.The different methods were used to guide the patients' diet,the improved quality were oberseved in the two groups after 3 ~6 months.Results In the observation group 108 cases of children with functional gastrointestinal disease,1 ~ 10 kinds of inequality of food allergen specific IgG children have increased in 90 cases,accounting for 83.3%,whereas the control group had 9 cases,only accounting for 25.0% (x2 =20.87,P < 0.05).In the observation group,the foods with highest sensitivity were milk,egg white/yellow,respectively for 84 patients (77.8%) and 60 cases (55.6%).Serum total IgE level between the observation group and control group had no significant difference (P > 0.05).17 cases (15.7%) within one month,the symptoms were improved,13 cases (12.1%) in three months,the symptoms were improved,the symptoms of 21 cases (19.4%) were not improved after 3 months.The total effective rate was 80.6%.Conclusions Children with functional gastrointestinal decease is easily to occur allergy caused by different food,and IgG antibody level can correctly reflect the relationship between them,reasonable diet can improve the symptoms of functional gastrointestinal disease.

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