咪达唑仑靶控输注时镇静深度与Narcotrend指数的相关性研究
Study on correlation between depth of sedation and Narcotrend index in Midazolam target-controlled infusion
目的 探讨Narcotrend用于咪达唑仑镇静深度监测的可靠性及镇静深度[改良警觉镇静评分(OAA/S)]与Narcotrend指数的相关性.方法 选择ASA Ⅰ~Ⅱ级择期行椎管内麻醉下下肢手术患者60例,给予静脉靶控输注咪达唑仑,血浆靶控浓度从50 ng/ml开始,以10 ng/ml的梯度逐步升高目标浓度,每一阶段维持5 min,当OAA/S评分为1分时停药,观察至OAA/S评分达5分,若手术尚未结束,调控至合适的镇静深度直至手术结束,记录不同OAA/S评分时的Narcotrend指数、心率、平均动脉压、呼吸的变化.结果 镇静加深期、恢复期OAA/S评分与Narcotrend指数均显著相关(r=0.786、0.652,均P<0.05).结论 Narcotrend 能很好指导咪达唑仑靶控输注,其指数与咪达唑仑镇静深度密切相关.
更多Objective To investigate the reliability of Narcotrend for monitoring the depth of sedation [the observer's assessment of alterness/sedation(OAA/S) scale] with midazolam and correlation between the depth of sedation and Narcotrend index.Methods 0 ASA Ⅰ-Ⅱ status patients scheduled for elective lower limb operations underwent spinal anesthesia,who were given target-controlled infusion of midazolam.Target plasma concentration was 50ng/ ml at first and increased by 10 ng/ml each grade until OAA/S scale became 1 point.Each target concentration infusion was maintained for 5min.Observe the patient the OAA/S scale to be 5 points.If the operation was not over yet,regulated the appropriate depth of sedation until the end of operation.The Narcotrend index of different OAA/S scale and heart rate,mean arterial pressure,respiration were recorded.Results In the deepening or recovery phase of sedation,OAA/S scales were correlated with Narcotrend index (Spearman' s r =0.786,0.652,all P < 0.05).Conclusion Narcotrend is a good index to guide target controlled infusion of midazolam,the index is closely related with the depth of sedation of midazolam.
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