血清肿瘤标志物联合检测在肺癌诊断中的临床应用
Clinical application of combined detection of serum tumor markers in diagnosis of lung cancer
目的 探讨血清肿瘤标志物联合检测在肺癌诊断中的意义,并选出敏感性最高的血清肿瘤标志物组合.方法 应用酶联免疫吸附法检测62例肺癌患者和62例健康体检者血清中神经元特异性烯醇化酶(NES)、糖链抗原125(CA125)、细胞角蛋白19(CYFRA21-1)及癌胚抗原(CEA)的含量水平.结果 肺癌组患者血清CEA、CA125、CYFRA21-1及NES水平均高于对照组(均P<0.05);在4种肿瘤标志物中,CA125的敏感性最高(59.7%),其次为CEA(53.2%);4种标志物联合检测的敏感性为87.1%,3种标志物联合检测中,以CEA+ CA125+ CYFRA21-1敏感性最高,为85.5%,2种标志物联合检测中CEA+ CA125敏感性最高,为75.8%.结论 4种血清肿瘤标志物对于肺癌的辅助诊断有一定的临床意义,CEA、CA125、CYFRA21-1可作为联合检测肺癌的首选标志物,具有较高的敏感性.
更多Objective To investigate the significance of combined detection of serum tumor markers in the diagnosis of lung cancer,and to select the most sensitive serum tumor markers.Methods Enzyme-linked immunosorbent assay was used to detect the serum tumor markers of 62 lung cancer patients and 62 healthy persons,who were neuron specific enolase enzyme (NES),carbohydrate antigen 125 (CA 125),cytokeratin 19 (CYFRA21-1) and carcinoembryonic antigen(CEA).Results The level of serum CEA,CA125,CYFRA21-1,and NES of the lung cancer group were all higher than those of the control group (all P < 0.05).Among the four kinds of tumor markers,CA125 had the highest sensitivity(59.7%),which was followed by CEA(53.2%).The sensitivity of the four kinds of joint detection was 87.1%,the highest sensitivity of three markers joint detection was CEA + CA125 + CYFRA21-1 (87.1%),while that of the two kinds of joint detection was CEA + CA125 (75.8%).Conclusion There are high clinical significance in the diagnosis of lung cancer with four kinds of serum tumor markers,CEA + CA125 + CYFRA21-1 can be used as the best markers for joint detection of lung cancer with high sensitivity.
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