来曲唑联合二甲双胍改善多囊卵巢综合征不孕症的效果分析
The effect of letrozole plus metformin on infertility of polycystic ovary syndrome
目的 研究来曲唑联合二甲双胍改善多囊卵巢综合征不孕症的效果.方法 90例多囊卵巢综合征不孕症患者采用数字表法随机分为治疗组45例,采用来曲唑联合二甲双胍治疗;对照组45例,采用氯米酚治疗,治疗后比较患者的排卵率、妊娠率、性激素、胰岛素抵抗.结果 治疗组治疗前后胰岛素抵抗指数(HOMA-IR)为(5.72±2.37),(3.16±1.39);对照组治疗前后HOMA-IR为(5.69±2.40),(4.81±2.06).治疗组治疗后明显降低HOMA-IR,并且降低程度大于对照组(t=3.7246,P<0.05).治疗组总排卵率80%,对照组总排卵率60%,两组差异有统计学意义(x2=4.06,P<0.05);治疗组妊娠率48.9%,对照组妊娠率28.9%,两组差异有统计学意义(x2=5.77,P<0.05).结论 来曲唑联合二甲双胍可以通过促排卵,减少胰岛素抵抗而增加多囊卵巢综合征不孕患者的受孕率.
更多Objective To study the effect of letrozole plus metformin on infertility of polycystic ovary syndrome(PCOS).Methods According to the digital table,90 patients with infertility of PCOS were randomly divided into the control group(n =45 cases) and the treatment group(n =45 cases).The patients of the control group were treated though clomiphene,while the patients of the treatment group were treated though letrozole plus metformin.The ovulation rate,pregnancy rate,sex hormones and insulin resistance were detected.Results The homeostasis model assessment of insulin resistance index (HOMA-IR) was (5.72 ± 2.37) before treatment and (3.16 ± 1.39) after treatment in the treatment group.HOMA-IR was (5.69 ± 2.40) before treatment and (4.81 ± 2.06) after treatment in the control group.There was a significantly decrease in the treatment group (t =3.7246,P < 0.05).The ovulation rate was 80% in the treatment group,while 60% in the control group,the difference between the two groups was significant(x2 =4.06,P <0.05).The pregnancy rate was 48.9% in the treatment group,while 28.9% in the control group,the difference between the two groups was significant (x2 =5.77,P < 0.05).Conclusion Letrozole plus metformin could promote the ovulation and decrease insulin resistance.
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