检索历史 清除

目的：探讨Ⅰ期切除吻合术对左半结肠癌急性肠梗阻患者血清胰岛素样生长因子-1（ IGF-1）和血管内皮生长因子（ VEGF）的影响。方法92例左半结肠癌急性肠梗阻患者按数字表法随机分为观察组46例、对照组46例，观察组采用Ⅰ期切除吻合术，对照组采用Hartman术，术前、术后测定两组患者血清IGF-1和VEGF的表达。结果观察组住院时间为（14．9±6．4）d，短于对照组的（28．3±9．6）d（t＝5．426，P＜0.05）；观察组切口感染、吻合口瘘分别为2例、1例，对照组分别为3例、1例，两组差异均无统计学意义（χ2＝2.19、1．29，均P＞0．05）；两组术后血清IGF-1和VEGF均明显降低，与对照组比较，观察组降低更明显（ t＝3.064、2．394，均P＜0．05）。结论Ⅰ期切除吻合术可以明显减少左半结肠癌急性肠梗阻患者血清IGF-1和VEGF的表达。

Objective To study the effectiveness of phase Ⅰleft colon resection and anastomosis on serum insulin-like growth factor-1(IGF-1) and vascular endothelial growth factor (VEGF) in patients with acute intestinal obstruction.Methods 92 patients with acute intestinal obstruction were randomly divided into two groups ,the obser-vation group(n=46) and the control group(n=46).The patients in the observation group were operated through phase Ⅰleft colon resection and anastomosis ,while the patients in the control group were operated through Hartman . Serum IGF-1 and VEGF were measured in preoperative and postoperative patients .Results The observation group for the length of time (14.9 ±6.4)d,shorter than the control group(28.3 ±9.6)d(t=5.426,P<0.05);observation group,incision infection,anastomotic leakage were 2 cases,1 cases,the control group was 3 cases,1 cases,no signifi-cant difference between two groups (χ2 =2.19,1.29,all P>0.05);two groups of postoperative serum levels of IGF-1 and VEGF were significantly decreased ,compared with the control group ,the observation group was significantly lower (t=3.064,2.394,all P<0.05).Conclusion Phase Ⅰ left colon resection and anastomosis can significantly de-crease serum IGF-1 and VEGF levels in patients with acute intestinal obstruction .