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目的：探讨冠心病心力衰竭患者血浆脑钠肽（ BNP）、高敏C反应蛋白（ hs-CRP）水平变化的意义。方法选择冠心病心力衰竭患者160例为观察组，健康人群200例为对照组，对BNP和hs-CRP进行检测分析。结果观察组BNP和hs-CRP分别为（481．5±57．8） pg/mL和（12．4±2．9） mg/mL，均高于对照组[（41．2±9.6）pg/mL）和（3.8±1．1）mg/L]，差异有统计学意义（t＝13．17，5．28，均P＜0．05）；观察组左室射血分数（LVEF）为（41．9±6．3）％，低于对照组的（60．2±8．4）％，差异具有统计学意义（t＝7．94，P＜0．05）；随心功能（Ⅰ级、Ⅱ级、Ⅲ级和Ⅳ级）变化BNP和hs-CRP均随着分级的增加逐渐增高，差异均具有统计学意义（ t＝5．20、10．11、12．42、4．18、5．02、3．98，均P＜0．05）。经Logistic分析，血清BNP和hs-CRP与冠心病心力衰竭相关。结论冠心病心力衰竭患者心功能与BNP和hs-CRP相关，随着分级的增加BNP和hs-CRP均逐渐增高。

Objective To investigate the relationship between coronary heart disease patients with heart fail -ure and natriuretic peptide ( BNP) and c-reactive protein ( hs-CRP) ,and provide the clinical basis .Methods 160 cor-onary heart disease patients with heart failure were selected as the observation group ,and 200 health individuals as the control group .The BNP and hs-CRP with heart failure were analyzed .Results BNP and hs-CRP of the observation group were(481.5 ±57.8)pg/mL and(12.4 ±2.9)mg/L,which were higher than that of the control group [(41.2 ± 9.6)pg/L vs(3.8 ±1.1)mg/L],the difference was statistically significant (t=13.17,5.28,all P<0.05);Left ven-tricular ejection fraction(LVEF)of the observation group was (41.9 ±6.3)%,lower than that of the control group (60.2 ±8.4)%,the difference was statistically significant (P<0.05);BNP and hs-CRP of grade Ⅰ,Ⅱ,Ⅲ and Ⅳincreased with the grade ,the differences were statistically significant ( t=5.20,10.11,12.42,4.18,5.02,3.98,all P<0.05);By Logistic analysis,serum BNP and hs-CRP were associated with heart failure of coronary heart disease . Conclusion Coronary heart disease patients with heart failure cardiac function were associated with BNP and hs -CRP,and with grade were gradually increasing that BNP and hs-CRP increased.