热疗联合化疗治疗晚期非小细胞肺癌伴神经内分泌化的临床研究
Clinical study of thermotherapy with chemotherapy in advanced non-small cell lung cancer with neuroendocrine differentiation
目的 探讨热疗联合化疗治疗晚期非小细胞肺癌伴神经内分泌化(NSCLC-NED)的临床疗效.方法 回顾性分析16例NSCLC-NED患者的临床资料,所有患者接受含铂类联合方案化疗,同时给予局部热疗,随访其疗效及生存情况.结果 16例患者中部分缓解(PR)7例,稳定(SD)4例,近期有效率(RR)43.8%,1年生存率为37.5% (6/16),生活质量改善率62.5% (10/16).结论 神经内分泌分化是NSCLC生物学行为的重要指标,化疗联合热疗安全、有效.
更多Objective To study the clinical efficacy of thermotherapy combined chemotherapy in the treatment of the advanced non-small cell lung carcinoma with neuroendocrine differentiation (NSCLC-NED).Methods The clinical data of 16 patients with NSCLC-NED were retrospectively reviewed.To analyzed the efficacy and survival of these patients.All patients were treated by thermotherapy with the combined chemotherapy regiment of platinum agents.Results There were 7 partial responses and 4 stable disease,The overall response rate (RR) was 43.8%.The one year survival rate was 37.5% (6/16).The improvement rate of quality of life was 62.5% (10/16).Conclusion Neuroendocrine differentiation is an important indicator of biological behavior of NSCLC.Thermochemotherapy is an active regimen in the advanced NSCLC-NED with an acceptabe toxicity.
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