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超早期尿激酶静脉溶栓治疗急性脑栓塞78例疗效观察

Curative effect of ultra early intravenous thrombolysis with urokinase on 78 cases with acute cerebral embolism

摘要:

目的 探讨超早期尿激酶静脉溶栓治疗急性脑栓塞的临床疗效及对神经功能缺损的影响.方法 将78例急性脑栓塞患者按照就诊顺序分为两组,每组各39例,对照组采取常规治疗,观察组在对照组基础上加用尿激酶静脉溶栓治疗,比较两组临床治疗效果及患者治疗前后神经功能缺损评分变化.结果 观察组总有效率为92.3%,显著高于对照组的74.4%(x2 =8.332,P<0.05);观察组治疗后24 h和21 d时美国国立卫生院卒中量表评分分别为(15.63 ±1.78)分和(7.85±1.74)分,明显低于对照组的(19.44±2.05)分和(11.32±1.93)分,两组差异均有统计学意义(t=9.06、9.15,均P<0.05);两组不良反应发生率差异无统计学意义(x2 =1.002,P>0.05).结论 超早期尿激酶静脉溶栓治疗急性脑栓塞疗效显著,可较好的减轻患者神经功能缺损,改善患者预后.

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Objective To investigate the clinical efficacy of ultra-early intravenous thrombolysis with urokinase for acute cerebral embolism and its effects on neurological impairment.Methods 78 patients with acute cerebral embolism were randomly divided into the two groups according to the order of treatment,and 39 cases in each group.The control group was given conventional treatment,while the observation group was given urokinase thrombolytic therapy.The clinical outcomes and neurological function changes were compared between the two groups.Results The total effective rate of the observation group was 92.3%,which was significantly higher than 74.4% of the control group (x2 =8.332,P < 0.05).After treatment,the 21 d and 24h NIHSS score of the observation group were (15.63 ± 1.78) points and (7.85 ± 1.74) points,which were significantly lower than (19.44 ± 2.05) points and (11.32 ± 1.93) points of the control group,the differences were statistically significant(t =9.06,9.15,all P < 0.05).There was no significant difference in adverse reactions between the two groups (x2 =1.002,P > 0.05).Conclusion The ultra-early intravenous thrombolysis with urokinase for acute cerebral embolism has significant effect,and it can reduce neurologic impairment,improve clinical outcomes,which is worth to be further promoted and applied in clinical.

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